Hydroxypropyl-?-Cyclodextrin for Delivery of Sinapic Acid via Inclusion Complex Prepared by Solvent Evaporation Method

The goal of this study was to increase the aqueous solubility and dissolution rate sinapic acid (SA) by formulating binary inclusion complex (BIC) SA with hydroxypropyl-?-cyclodextrin (HP?CD) using solvent evaporation (SE) technology. phase studies were conducted determine in vitro release SA. In addition, prepared characterized for solid state characterization techniques such as DSC, PXRD, SEM, FTIR. Moreover, SA-BIC evaluated its antioxidant activity. Results revealed that can be shown improve a change HP?CD concentration. About 2.59 times higher water noticed presence (10 mM). Dissolution demonstrated 34.11 ± 4.51% released from physical mixture (BPM), while maximum 46.27 2.79% observed SE method. distinctive properties when compared pure SA, which different analytical methods, FTIR, evidence into cavity. Further, it displayed stronger DPPH radical scavenging activity than conclusion, technology considerably enhanced complexity HP?CD, these observations could help heighten solubility, may lead better bioavailability.